Michael J Davies Selected Research

Hypochlorous Acid (Hypochlorite)

1/2021	Modulation of hypochlorous acid (HOCl) induced damage to vascular smooth muscle cells by thiocyanate and selenium analogues.
1/2020	Myeloperoxidase-derived damage to human plasma fibronectin: Modulation by protein binding and thiocyanate ions (SCN-).
1/2019	Chlorination and oxidation of the extracellular matrix protein laminin and basement membrane extracts by hypochlorous acid and myeloperoxidase.
1/2016	Cellular targets of the myeloperoxidase-derived oxidant hypothiocyanous acid (HOSCN) and its role in the inhibition of glycolysis in macrophages.
6/2013	The modern pharmacology of paracetamol: therapeutic actions, mechanism of action, metabolism, toxicity and recent pharmacological findings.
11/2012	Computational design of effective, bioinspired HOCl antioxidants: the role of intramolecular Cl+ and H+ shifts.
5/2009	What are the plasma targets of the oxidant hypochlorous acid? A kinetic modeling approach.
9/2008	Hypochlorous acid oxidizes methionine and tryptophan residues in myoglobin.

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Michael J Davies Research Topics

Disease

53	Inflammation (Inflammations) 01/2022 - 01/2002
43	Type 2 Diabetes Mellitus (MODY) 01/2018 - 05/2005
37	Atherosclerosis 01/2022 - 04/2002
17	Hypoglycemia (Reactive Hypoglycemia) 01/2018 - 12/2005
10	Cardiovascular Diseases (Cardiovascular Disease) 01/2020 - 05/2004
9	Body Weight (Weight, Body) 01/2021 - 02/2008
8	Hypertension (High Blood Pressure) 01/2018 - 08/2004
7	Asthma (Bronchial Asthma) 03/2011 - 04/2004
7	Coronary Disease (Coronary Heart Disease) 05/2006 - 10/2003
6	Infections 01/2021 - 10/2005
6	Neoplasms (Cancer) 01/2017 - 01/2002
5	Type 1 Diabetes Mellitus (Autoimmune Diabetes) 01/2021 - 01/2013
5	Cataract (Cataracts) 10/2016 - 07/2002
5	Atherosclerotic Plaque (Atheroma) 05/2015 - 03/2003
3	Psoriasis (Pustulosis Palmaris et Plantaris) 01/2022 - 01/2021
3	Disease Progression 01/2022 - 11/2003
3	Multiple Sclerosis 01/2022 - 01/2021
3	Necrosis 01/2021 - 09/2008
3	Fibrosis (Cirrhosis) 01/2021 - 01/2013
3	Weight Loss (Weight Reduction) 01/2018 - 08/2002
3	Insulin Resistance 01/2018 - 05/2002
3	Metabolic Syndrome (Dysmetabolic Syndrome X) 01/2017 - 07/2004
3	Infertility (Sterility) 10/2016 - 09/2003
3	Rupture 01/2016 - 02/2002
3	Systemic Lupus Erythematosus (Libman-Sacks Disease) 02/2009 - 07/2005
3	Hyperlipidemias (Hyperlipidemia) 06/2008 - 04/2006
2	Parkinson Disease (Parkinson's Disease) 01/2022 - 04/2002
2	Chronic Renal Insufficiency 01/2022 - 07/2010
2	Diabetic Ketoacidosis (Ketoacidosis, Diabetic) 01/2021 - 11/2020
2	Reperfusion Injury 01/2021 - 12/2015
2	Weight Gain 01/2021 - 07/2004
2	Overweight 01/2021 - 01/2018
2	Heart Failure 08/2017 - 03/2015
2	Urinary Tract Infections (Urinary Tract Infection) 01/2017 - 06/2016

Drug/Important Bio-Agent (IBA)

29	Oxidants (Oxidizing Agents)IBA 01/2022 - 11/2003
28	Proteins (Proteins, Gene)FDA Link 01/2022 - 04/2002
24	Peroxidase (Myeloperoxidase)IBA 09/2021 - 05/2009
20	Sitagliptin Phosphate (Januvia)FDA Link 01/2017 - 12/2005
15	Glucose (Dextrose)FDA LinkGeneric 01/2021 - 05/2002
15	LipidsIBA 01/2017 - 04/2002
14	Hypoglycemic Agents (Hypoglycemics)IBA 03/2015 - 11/2006
13	EnzymesIBA 01/2021 - 07/2002
11	oxidized low density lipoproteinIBA 01/2016 - 04/2003
9	Insulin (Novolin)FDA Link 01/2021 - 05/2002
8	Hypochlorous Acid (Hypochlorite)IBA 01/2021 - 09/2008
8	Biomarkers (Surrogate Marker)IBA 01/2021 - 07/2008
8	SymportersIBA 01/2021 - 06/2016
8	SodiumIBA 01/2021 - 06/2016
8	Peroxynitrous Acid (Peroxynitrite)IBA 01/2019 - 04/2007
8	CanagliflozinIBA 01/2018 - 06/2016
8	Triglycerides (Triacylglycerol)IBA 01/2017 - 05/2002
8	hypobromous acidIBA 06/2013 - 10/2005
8	CholesterolIBA 01/2013 - 04/2002
7	Metformin (Glucophage)FDA LinkGeneric 01/2018 - 03/2009
7	IonsIBA 10/2016 - 05/2004
6	SeleniumIBA 01/2021 - 12/2011
6	Sodium-Glucose Transporter 2 InhibitorsIBA 01/2021 - 06/2016
6	LDL CholesterolIBA 01/2017 - 10/2003
6	LDL Lipoproteins (beta Lipoproteins)IBA 05/2015 - 04/2002
6	Ezetimibe (Zetia)FDA Link 06/2008 - 07/2005
6	Simvastatin (Zocor)FDA LinkGeneric 02/2007 - 07/2004
5	Pharmaceutical PreparationsIBA 01/2022 - 10/2008
5	Biological ProductsIBA 01/2021 - 10/2005
5	thiocyanateIBA 01/2021 - 11/2011
4	CytokinesIBA 09/2021 - 02/2014
4	(2S,3R,4R,5S,6R)- 2- (4- chloro- 3- (4- ethoxybenzyl)phenyl)- 6- (methylthio)tetrahydro- 2H- pyran- 3,4,5- triolIBA 01/2021 - 11/2020
4	Heme (Haem)IBA 01/2021 - 05/2009
4	glimepiride (Amarel)FDA LinkGeneric 01/2018 - 06/2011
4	Hydroxymethylglutaryl-CoA Reductase Inhibitors (HMG-CoA Reductase Inhibitors)IBA 01/2017 - 05/2011
4	MetalsIBA 10/2016 - 05/2004
4	Sulfhydryl Compounds (Thiols)IBA 12/2015 - 07/2009
4	Blood Proteins (Serum Proteins)IBA 11/2011 - 07/2005
4	GlycosaminoglycansIBA 08/2009 - 11/2003
3	Dimethyl FumarateIBA 01/2022 - 01/2021
3	PeroxidasesIBA 01/2021 - 07/2008
3	Tyrosine (L-Tyrosine)FDA Link 01/2019 - 11/2004
3	CarnosineIBA 01/2019 - 03/2007
3	Adrenal Cortex Hormones (Corticosteroids)IBA 10/2016 - 11/2004
3	Crystallins (Crystallin)IBA 10/2016 - 11/2004
3	CollagenIBA 09/2016 - 01/2013
3	Cholesterol Esters (Cholesteryl Esters)IBA 01/2011 - 09/2003
3	IncretinsIBA 04/2010 - 11/2006
3	Fenofibrate (CiL)FDA LinkGeneric 06/2008 - 04/2006
3	Dipeptidyl-Peptidase IV InhibitorsIBA 02/2008 - 01/2006
3	Glucagon-Like Peptide 1 (GLP 1)IBA 11/2006 - 12/2005
2	Muramidase (Lysozyme)IBA 01/2021 - 11/2005
2	CalciumIBA 01/2021 - 06/2012
2	Protective AgentsIBA 01/2020 - 03/2018
2	Fibronectins (Fibronectin)IBA 01/2020 - 01/2016
2	Laminin (Merosin)IBA 01/2019 - 04/2014
2	3-chlorotyrosineIBA 01/2019 - 01/2019
2	LeptinIBA 01/2018 - 05/2004
2	AdipokinesIBA 01/2018 - 05/2015
2	A-factor (Streptomyces)IBA 01/2017 - 11/2003
2	HDL CholesterolIBA 01/2017 - 06/2008
2	Superoxides (Superoxide)IBA 12/2015 - 01/2002
2	ChloraminesIBA 07/2015 - 01/2002

Therapy/Procedure

17	Therapeutics 01/2021 - 05/2004
8	Glycemic Control 01/2018 - 02/2008
3	Lenses 02/2014 - 11/2004